[ccp4bb] Post doc position in Oulu

Dear all,

There is an opening for a post doc with experience in recombinant protein production and purification, enzyme kinetic analyses and structural biology (crystallization, cryoEM) in our group in University of Oulu, Finland. Our research focuses on the enzyme family of 2-oxoglutarate-dependent dioxygenases and their potential as therapeutic targets. Our main interests are in the hypoxia-inducible factor prolyl 4-hydroxylases, P4H-TM and histone demethylases. We offer a research environment with excellent technological facilities and a motivating and supporting community. Deadline Feb 21.

More information: https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=00008708&lang=fi

Recent publications:

Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock BA, Jaffe JD, Haigis MC, Beroukhim R, Signoretti S, Koivunen P, Kaelin WG Jr. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science. 2019 Mar 15;363(6432):1217-1222.

Laukka T, Myllykoski M, Looper RE, Koivunen P. Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases. J Mol Biol. 2018 Sep 14;430(18 Pt B):3081-3092.

Rahikkala E, Myllykoski M, Hinttala R, Vieira P, Nayebzadeh N, Weiss S, Plomp AS, Bittner RE, Kurki MI, Kuismin O, Lewis AM, Väisänen ML, Kokkonen H, Westermann J, Bernert G, Tuominen H, Palotie A, Aaltonen L, Yang Y, Potocki L, Moilanen J, van Koningsbruggen S, Wang X, Schmidt WM, Koivunen P, Uusimaa J. Biallelic loss-of-function P4HTM gene variants cause hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities (HIDEA syndrome). Genet Med. 2019 Oct;21(10):2355-2363.

Peppi Karppinen (Koivunen), MD, PhD

Professor, Dean

University of Oulu

Faculty of Biochemistry and Molecular Medicine

Room L203 │ Aapistie 7A │FIN-90014 University of Oulu

FINLAND

_____________________________________________

Email peppi.karppinen@oulu.fi

Phone +358 (0) 294 485822

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