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[ccp4bb] Structural Biology Scientist position at Foghorn Therapeutics in Cambridge, MA, USA

Foghorn Therapeutics has an exciting job opportunity for an early career Scientist in Structural Biology. Please apply directly to the official posting:





TITLE:                  Scientist, Structural Biology

REPORTS TO:     Principal Scientist, Drug Discovery

LOCATION:        Cambridge, MA


Through its Gene Traffic Control Product Platform, Foghorn® Therapeutics is discovering and developing an unprecedented class of medicines targeting diseases with genetically determined dependencies in the chromatin regulatory system. The Company, currently pre-clinical stage, is rapidly advancing over 10 programs across a wide range of cancers and is beginning to explore other diseases.

The chromatin regulatory system orchestrates the movement of molecules that turn genes on and off. Disease dependencies associated with chromatin dysregulation are estimated to impact approximately 2.5 million cancer patients in G7 countries and chromatin dysregulation is further implicated in neurological, autoimmune, and other serious diseases. Foghorn’s proprietary Gene Traffic Control Product Platform is based on the Company’s unique insights into the chromatin regulatory system and enables highly scalable drug discovery and development efforts.

Foghorn, a Flagship Pioneering® company, was founded in 2016 by Cigall Kadoch, Ph.D., Gerald Crabtree, M.D., and Doug Cole, M.D., of Flagship Pioneering. Learn more about Foghorn at www.foghorntx.com.  

We are seeking a highly skilled and motivated structural biologist to become an integral member of the Foghorn team. This person will contribute to our goal of developing transformative therapeutics by planning and carrying out structural characterization of crucial drug targets. The main focus of this role will be protein crystallography but will require a willingness to find new ways to think about scientific challenges. We need someone who is passionate, driven, and ambitious to help us achieve our goal of improving patients’ lives. 

Responsibilities include:

  • Collaborating with colleagues in biochemistry, biology, and chemistry to develop structural biology strategy.
  • Designing biophysics-grade protein constructs and assisting in the optimization of purification protocols.
  • Crystallization, X-ray structure determination, and analysis of important drug targets.
  • Providing regular updates to cross-functional teams and helping guide structure-based compound design in close collaboration with medicinal and computational chemists.
  • Participating in the management of collaborations with contract research organizations (CROs) and academic partners.


  • PhD in Structural Biology, Biophysics, Biochemistry or a closely related field, with a background in chemistry.
  • Demonstrated competency in protein construct design and _expression_ and purification strategies using bacterial, insect, and mammalian hosts. Experience with multi-protein complexes is a plus. 
  • Deep expertise in protein crystallization and X-ray structure determination of protein-ligand complexes.
  • Extensive knowledge of protein structure and function, with the ability to articulately communicate structural information to a broad audience.
  • Experience with other structural techniques (e.g. electron microscopy, small-angle X-ray scattering) is strongly preferred.
  • Excellent time management and communication skills. 
  • Ability to work in a fast-paced, team-driven environment, with a collaborative and proactive attitude.


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Jeremy W. Setser, PhD

Principal Scientist, Drug Discovery

Foghorn Therapeutics






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