Neurophysiology/structural biology/microbiology PhD project: Bacterial infections targeting synaptic adhesion molecules: effects of bacterial adhesin binding to adhesive components of photoreceptor/retinal synapses
Project Description
We are looking to recruit a highly motivated PhD student for a joint research project between the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS, Saarbrücken, Germany - a branch of the Helmholtz Centre for Infection Research) and Saarland Medical University (UKS, Homburg, Germany).
The project on bacterial adhesins binding to neuronal structures is highly interdisciplinary and ranges from molecular microbiology/structural biology to neurophysiology and will include bacterial and mammalian protein _expression_, crystallization studies, synaptic physiology using genetically engineered reporter mice, Ca2+ imaging, cell wall associated proteome studies, and different adhesion assays including single molecule force spectroscopy.
The position is fully funded for 3 years (50%, TV-L E13). The desired starting date is between 11/2019 and 02/2020. Further information on the three research groups of
Prof. Dr. Schmitz (https://www.uniklinikum-saarland.de/einrichtungen/fachrichtungen/anatomie_zellbiologie_und_entwicklungsbiologie/univ_prof_dr_med_frank_schmitz_anatomie/)
Prof. Dr. Köhnke (https://www.helmholtz-hzi.de/koehnke), and
Prof. Dr. Bischoff (https://www.uniklinikum-saarland.de/einrichtungen/kliniken_institute/infektionsmedizin/medizinische_mikrobiologie_und_hygiene/forschung/)
can be found online.
The ideal candidate has a MSc degree in Biology (or related) with previous MSc thesis research expertise in neurophysiology, structure biology, and/or microbiology. Willingness to routinely work under biosafety S2 level and with mice is essential.
Applications are only accepted electronically as a single PDF file containing the relevant information (motivation letter, CV, A-level/BSc/MSc diplomas, transcripts of records, names of 2 references, and, if available, letters of recommendation). Please send them to all three email addresses (Frank.Schmitz@uks.eu, Jesko.Koehnke@helmholtz-hips.de and markus.bischoff@uks.eu) parallel. Applications will be continuously reviewed until the position has been filled.
Funding Notes
All students holding an MSc or an equivalent degree at the time of employment are eligible; EU and non-EU nationals are eligible.
Related Subjects
· Medical / Clinical Science
· Neurophysiology
· Structural Biology
· Microbiology
· Molecular Biology
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