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[ccp4bb] Senior Scientist opportunity in Protein Engineering within Sanofi Biologics Research

Hi all,

We have a new Senior Scientist opportunity in Protein Engineering within Sanofi Biologics Research.  Please follow the link below for application information.  


  • Senior Scientist- Framingham/MA

    Job Description

    A highly motivated structural biologist is sought to join our structural biology team in Protein Engineering within Sanofi US Biologics Research department. We use leading edge crystallography, cryoEM, and computational modeling tools to support different project needs from Sanofi’s multi-targeting multi-modality research pipeline. Our structural biology team has a great track record of publications in the area of biologics characterization, antibody engineering and multi-specific antibodies.

    Job role

    • Work closely with experienced scientists in a dynamic and highly collaborative global environment.
    • Plan with project teams to address their questions of biologics candidate with customized structural biology tools.
    • Deliver high quality structural information of antibody antigen complex using crystallography, cryoEM, and HDX-MS as needed.
    • Provide structure based analysis and rational design with computational programs to optimize biologics candidate, including epitope analysis and comparison, structure-function relationship, developability risk mitigation, stability, humanization/simianization, and affinity variation.

    Basic qualifications

    • Ph.D. in protein crystallography, cryoEM, or equivalent with less than 5 years of postdoctoral or industrial experience.
    • Proven in-depth knowledge and expertise in protein structural biology and biochemistry demonstrated preferably through principal authorship in peer-reviewed publication(s).
    • Specifically, candidate must have extensive experience in protein construct optimization, protein purification, data collection and structure determination either with crystallography or cryoEM with strong protein chemistry skills.
    • Expertise in common crystallography or cryoEM software and refinement at low resolution are required.

    Preferred Qualifications

    • Strong and consistent written and oral communication ability in professional settings.
    • Experience with biochemical biophysical assays/techniques (DLS, MALS, DSF, HPLC, AUC) and mass spectrometry.
    • Knowledge of antibody structures, experience with CRO or project management are also desirable.
    • Experience with developability prediction and engineering.
    • Familiarity with lab robotics and automation and other protein biophysical characterization techniques is preferred.
    • Programming skill with Python, Perl, MATLAB, etc is a plus.

    Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or _expression_; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

    At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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