Domainex has a full-time permanent vacancy in our Protein Science Team, which offers our clients a comprehensive
range of services including molecular biology, protein production for assays and structural biology, and structural analysis of proteins by X-ray crystallography. Our unique, patented, Combinatorial Domain Hunting technology allows us to make and work with
proteins that are otherwise refractory to recombinant _expression_.
All applicants must be able to solve X-ray crystal structures independently and have a good working knowledge of the current software packages employed in protein crystallography (esp.
XDS, CCP4, coot). They should be able to demonstrate postdoctoral level experience of solving structures of protein-ligand complexes over a range of target classes in a drug discovery environment, experience in the use of biophysical techniques would be a
significant plus. Candidates must also have expertise in molecular biology; recombinant protein _expression_ and purification in E. coli,
insect or mammalian cells; and substantial experience of using AKTA chromatography equipment (or similar) for protein purification to X-ray crystallography standard.
This role requires the ability to plan and implement experimental programmes, to solve any problems that arise, and to work effectively within project teams to deliver high-quality results
to our clients. Laboratory work is a major element of this varied and challenging role. Essential attributes include diligent reporting of results, data interpretation, and an ability to make recommendations for further studies. It will also be necessary
to communicate your results effectively to our clients.
Job requirements:
PhD with track-record of relevant and proven experience, i.e. publications and PDB depositions.
Independence and team working; flexibility to take on different projects; ability to make a meaningful impact on clients.
Ability to work on your own initiative, and to consistently deliver high quality results.
Creative thinking coupled to delivery of novel outcomes that leads to opportunities for inventorship or publications (papers/research articles).
To apply for this role, please send your CV and a covering letter, quoting reference PS0519, to recruitment2019@domainex.co.uk.