[Date Prev][Date Next][Thread Prev][Thread Next][Date Index][Thread Index]

[ccp4bb] Postdoc position to study membrane protein structure

Postdoctoral Position at University of Texas McGovern Medical School at Houston

A postdoctoral position is available in the Department of Biochemistry and Molecular Biology at University of Texas McGovern Medical School in the laboratory of Dr. Lei Zheng to study the structure and regulatory mechanism of mammalian sodium/calcium exchanger proteins using X-ray crystallography and cryo-electron microscopy.  

Sodium/calcium exchanger proteins are involved in maintaining Ca2+ homeostasis in most mammalian tissues and play essential roles in cardiac contraction-relaxation and neuronal transmission.  The successful candidate will perform protein _expression_ and purification using insect cell systems, and use cryo-electron microscopy and single particle analysis approaches to study the structure of exchanger complex with small drug inhibitors. The fellow will also use X-ray crystallography and other biochemical approaches to study a novel regulatory mechanism of exchangers mediated by accessory proteins newly identified in our lab.

The ideal candidate should have a recent Ph.D. in Structural Biology and Biochemistry with demonstrated experience in protein _expression_, purification and characterization. Experience with membrane protein and insect cell culture will be a great asset.  The fellow will have an opportunity to work other groups in the department to learn cryo-Electron Microcopy.


The laboratory is located in Texas Medical Center, the largest campus for medical research in the world, which provides outstanding environments for academic development.  Houston is a highly culture-diversified city with affordable living costs. Salary will be based on NIH standard and individual experience.


Interested applicants should send their CV and three letters of reference to Dr. Lei Zheng (lei.zheng@uth.tmc,edu).



Lei Zheng, Ph.D.

Associate Professor

Center for Membrane Biology

Department of Biochemistry and Molecular Biology

University of Texas McGovern Medical School

6431 Fannin Street, MSB 6.218 (office), 6.408 (lab)

Houston, TX 77030

Tel: 713-500-6083 (office), -7451 (lab)

To unsubscribe from the CCP4BB list, click the following link: