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[ccp4bb] PhD/ postdoc positions on studies on the life cycle and applications of virophages: Max Planck Institute, Heidelberg, Germany



Ph.D. and Postdoctoral positions dedicated to biophysical and spectroscopic/structural studies on the life cycle of virophages and their applications as nano-containers available in Jochen Reinstein's lab http://www.mpimf-heidelberg.mpg.de/14072516/gruppereinstein
at the Max Planck Institute for Medical Research, Heidelberg.
http://www.mpimf-heidelberg.mpg.de/en

Project Description:
Virophages are small DNA viruses of unicellular eukaryotes that replicate only during a coinfection with a giant virus. They propagate at the expense of the giant virus using its cytosolic reproduction and assembly machinery. Virophages encode about 20 genes including two capsid proteins, a protease that assists maturation and a FtsK-HerA type ATPase that supposedly is responsible for ATP dependent DNA transport into the assembled capsid. The successful candidates will characterize capsid assembly & processing and active DNA transport of the Virophage. The assembly/-disassembly pathway will be characterized with spectroscopic, kinetic and structural methods with the aim to better understand the hierarchy and pathway of supramolecular organisation of capsid structure and what determines the exact size of assembled particles in the absence of a molecular ruler. Key to addressing these questions is the development and application of fluorescence based markers for FRET and Fluorescence Microscopy assays. The gained knowledge will be used for recruiting in vitro assembled capsids for in vivo studies in collaboration with Matthias Fischer http://www.mpimf-heidelberg.mpg.de/14071687/gruppefischer.
The department has ample synchrotron beamtime at the SLS.

Applicants:
Successful candidates have an excellent track record, high motivation, and broad scientific interests. They will join a multidisciplinary international team. They should hold a master’s (Ph.D. or equivalent for postdoctoral candidates) degree in Biochemistry or related fields. The working language of the project will be English. We offer excellent laboratory facilities tailored to the needs of the project. Payment is based on the TVöD guidelines.

Ph.D. candidates will have the opportunity to participate in one of several interdisciplinary Ph.D. programs in collaboration with the University of Heidelberg. The position is limited to three years with a possibility of extension. For postdoctoral applicants, the position is limited to two years with a possibility of extension.

In case of questions, please contact Jochen Reinstein (jochen.reinstein@mpimf-heidelberg.mpg.de)

Please submit your application containing a cover letter (explaining background and motivation), your CV, complete transcripts (for Ph.D. applicants) or summary of previous research experience with a list of publications (for postdoctoral applicants) via e-mail as a single PDF file to

jobs@vw.mpimf-heidelberg.mpg.de (reference nr. 05/2019)

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages their application. The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds. A daycare center for children is located close to the institute.

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