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[ccp4bb] PhD/ postdoc positions on studies on the life cycle and applications of virophages: Max Planck Institute, Heidelberg, Germany
Ph.D. and Postdoctoral positions dedicated to biophysical and
spectroscopic/structural studies on the life cycle of virophages and
their applications as nano-containers available in Jochen Reinstein's
lab http://www.mpimf-heidelberg.mpg.de/14072516/gruppereinstein
at the Max Planck Institute for Medical Research, Heidelberg.
http://www.mpimf-heidelberg.mpg.de/en
Project Description:
Virophages are small DNA viruses of unicellular eukaryotes that
replicate only during a coinfection with a giant virus. They propagate
at the expense of the giant virus using its cytosolic reproduction and
assembly machinery. Virophages encode about 20 genes including two
capsid proteins, a protease that assists maturation and a FtsK-HerA type
ATPase that supposedly is responsible for ATP dependent DNA transport
into the assembled capsid.
The successful candidates will characterize capsid assembly & processing
and active DNA transport of the Virophage. The assembly/-disassembly
pathway will be characterized with spectroscopic, kinetic and structural
methods with the aim to better understand the hierarchy and pathway of
supramolecular organisation of capsid structure and what determines the
exact size of assembled particles in the absence of a molecular ruler.
Key to addressing these questions is the development and application of
fluorescence based markers for FRET and Fluorescence Microscopy assays.
The gained knowledge will be used for recruiting in vitro assembled
capsids for in vivo studies in collaboration with Matthias Fischer
http://www.mpimf-heidelberg.mpg.de/14071687/gruppefischer.
The department has ample synchrotron beamtime at the SLS.
Applicants:
Successful candidates have an excellent track record, high motivation,
and broad scientific interests. They will join a multidisciplinary
international team. They should hold a master’s (Ph.D. or equivalent for
postdoctoral candidates) degree in Biochemistry or related fields. The
working language of the project will be English. We offer excellent
laboratory facilities tailored to the needs of the project. Payment is
based on the TVöD guidelines.
Ph.D. candidates will have the opportunity to participate in one of
several interdisciplinary Ph.D. programs in collaboration with the
University of Heidelberg. The position is limited to three years with a
possibility of extension.
For postdoctoral applicants, the position is limited to two years with a
possibility of extension.
In case of questions, please contact Jochen Reinstein
(jochen.reinstein@mpimf-heidelberg.mpg.de)
Please submit your application containing a cover letter (explaining
background and motivation), your CV, complete transcripts (for Ph.D.
applicants) or summary of previous research experience with a list of
publications (for postdoctoral applicants) via e-mail as a single PDF file to
jobs@vw.mpimf-heidelberg.mpg.de (reference nr. 05/2019)
The Max Planck Society is committed to increasing the number of
individuals with disabilities in its workforce and therefore encourages
their application. The Max Planck Society strives for gender and
diversity equality. We welcome applications from all backgrounds. A
daycare center for children is located close to the institute.
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