A fellowship-funded postdoc position is open in Dr Sebastian Zoll’s group at the Institute of Organic Chemistry and Biochemsitry (IOCB) in Prague. Dr Zoll’s group is using a combination of biochemical, biophysical, immunological and structural biology techniques to understand the mechanisms of host-pathogen interactions. The succesful candidate will use Cryo-EM to determine the structure of a viral capsid protein in complex with its cellular receptor. As part of this process the applicant will generate monoclonal antibody and nanobody libraries as tools as well as for therapeutic applications.
- PhD in structural biology using Cryo-EM as the main tool. Expertise in grid preparation, microscope operation and data processing in RELION is essential. Knowledge in X-ray crystallography and SAXS is a bonus but not necessary.
- Experience in _expression_ construct design, protein purification and biophysical techniques to analyse protein-protein interactions (ITC or SPR).
The project is supported by a multidisciplinary network of international collaborators and provides excellent opportunities to receive additional training in foreign host institutions.
The fellowship is granted for one year with possible extension by one more year. The earliest starting date is May 2020. For further information please see:
The institute and the city
IOCB Prague is the leading scientific research institution in the Czech Republic providing a dynamic, international environment that brings together researchers from various fields such as structural biology, molecular biology, medicinal and computational chemistry.
Due to its long-standing history in applied science and strong ties with the pharmaceutical industry, IOCB enjoys an excellent funding situation and offers access to facilities for all modern structural and biophysical methods.
The IOCB Cryo-EM facility housing a 300 keV high-resolution and 200 keV screening cryo-electron microscope will become operational next year. In the meanwhile IOCB researchers enjoy privileged access to the EM facilities (screening microscopes and Titan Krios G3) at CEITEC.
IOCB is situated near the city centre in a vibrating, historical quarter of Prague boasting beautiful architecture and a rich array of public amenities such as cafés, pubs, parks and grocery stores. Transport links by metro and tram are excellent with short distances to both airport as well as old town and Letna park with its stunning views over the Vltava river.
How to apply?
Please send a short motivation statement (max. 500 words) and a copy of your CV to email@example.com
Feel free to contact Sebastian for informal enquiries.
Dr Sebastian Zoll
Junior Group Leader
Institute of Organic Chemistry and Biochemistry
Czech Academy of Sciences
Flemingovo namesti 542/2, 166 10 Prague 6
Phone: +420 220 183 591
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