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[ccp4bb] Job: PDRA crystallography drug discovery protein production



Full time, fixed term contract until 31 December 2021.

https://www.jobs.ac.uk/job/BXB907/research-fellow-78236-119

Funding at level 6 is available for a maximum 18 months restricted to end by 31 December 21

CHNUK: Structural approaches to novel fragment based and natural product antibiotic discovery

Applications are invited for a highly motivated and experienced postdoctoral researcher to join an active research group at the School of Life Sciences, University of Warwick supervised by a team headed by Prof Chris Dowson. The project, which has been recently funded by the Newton Fund, focuses on acquiring specific structural and biochemical data using a novel strategy of HT affinity crystallography, using robust crystals of well validated and novel antibacterial targets to identify either fragment-based inhibitors or inhibitors identified by crystallography directly from complex mixtures of natural products. This position is available for up to 18 months in the first instance and will involve substantive interactions with academic colleagues at Harwell (Prof Frank vonDelft) and those in China at the Shanghai synchrotron.

You will have a PhD in a relevant field. The successful applicant should have proficiency in molecular cloning, protein expression, purification, crystallization, X-ray crystal structure determination in particular and should have a background in biochemistry or molecular biology/ drug discovery generally.

The School of Life Sciences at Warwick is equipped with state-of-the-art protein expression and purification apparatus, including high-throughput facilities for crystallisation and visualisation as well as regular synchrotron access in the UK and abroad. The wider laboratory is very well equipped with microbiological, biochemical and biophysical infrastructure and the successful applicant will join a wider team of highly motivated scientists working on a range of antimicrobial discovery and resistance projects.

Email: c.g.dowson@warwick.ac.uk

Website: https://warwick.ac.uk/fac/sci/lifesci/research/infdisease.

Closing date: 31 January 2020

Full details of the duties and selection criteria for this role can be found in the vacancy advert on the University of Warwick’s jobs pages. You will be routed to this when you click on the Apply button below.

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