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[ccp4bb] PhD project available - IMPACT: MRC Funded Doctoral Training Partnership

IMPACT: MRC Funded Doctoral Training Partnership
PhD Project Available

Deconstructing the Role of the MOZ/KAT6A Double Winged Helix Domain in Gene Regulation and Disease

Professor David M Heery 	University of Nottingham
Dr Ralf Flaig 			Diamond Light Source, Research Complex at Harwell 
Dr Ingrid Dreveny 		University of Nottingham


A PhD project (MRC Impact funded) is available in the Gene Regulation & RNA Biology Laboratory, University of Nottingham 
under the supervision of Professor David M Heery. 
The project will involve a structure/ function characterisation of a novel domain within the gene regulatory protein KAT6A/ MOZ. 
Mutations in this gene are associated with childhood leukemias and neurodevelopmental syndromes. KAT6A/ MOZ has multiple functions, 
one of which is an epigenetic regulator controlling histone acetylation. Our long-term aim is to understand the role of a 
double winged helix domain in the pathology of these conditions. The project will provide the opportunity to learn a range of molecular and 
cell biology techniques including protein purification/ crystallisation, DNA binding assays, site-directed mutagenesis and CRISPR CAS9 editing. 
The project involves a collaboration with Dr Ingrid Dreveny (Structural Biology) and Dr Ralf Flaig at Diamond Light Source/ Research Complex Harwell. 

For further information and details on how to apply please contact

david.heery@nottingham.ac.uk

Please note, IMPACT studentships are available to UK and EU nationals ONLY. For full details on eligibility, and the application process please refer to 
https://more.bham.ac.uk/mrc-impact/phd-opportunities/

https://www.findaphd.com/phds/project/deconstructing-the-role-of-the-moz-kat6a-double-winged-helix-domain-in-gene-regulation-and-disease/?p116979

The application deadline is 5.00pm Friday 17 January 2020.
Interviews will take place the week commencing 17 February 2020.


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Dr. Ralf Flaig               ralf.flaig@diamond.ac.uk
Principal Beamline Scientist, I04 Macromolecular Crystallography
Diamond Light Source, Harwell Science and Innovation Campus
Chilton, Didcot OX11 0DE, United Kingdom 
tel: +44 (0)1235 77 8412         fax: +44 (0)1235 77 8448
http://www.diamond.ac.uk/mx-home/






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