[ccp4bb] Two Post-Doctoral Positions at the Goethe University Frankfurt, Germany

[Klaas Pos <pos@EM.UNI-FRANKFURT.DE>]

Dear all,

I would like to bring the following post-doctoral positions to your attention. Thank you for allowing it to post here.

Kind regards,

Martin Pos


*Two Post-Doctoral Positions at the Goethe University Frankfurt, Germany*

An international (French/German) collaborative research program has recently been funded (ANR/BMBF) to investigate and develop a novel class of *efflux pump inhibitors in Gram-negative bacteria*. The project aims to fully elucidate the mechanism of action of the efflux pump inhibitors, understand the structural biology and perform medicinal chemistry to develop the inhibitors into drug like molecules for in vivo proof of concept. The bacteria of interest are E. coli, K. pneumoniae, A. baumannii and P. aeruginosa.

This application concerns *a postdoctoral researcher position* at the *Institute of Biochemistry*, in the department of Membrane Transport Machineries (Prof. Dr. Klaas M. Pos) and *a postdoctoral researcher position* at the *Institute of Biophysics* in the department of Cryo-Electron Microscopy (Prof. Dr. Achilleas Frangakis) at the *Goethe University Frankfurt*, Germany. In these closely collaborating teams, the research focus will be to define the molecular determinants of efflux pump inhibitor binding and its mechanism of action using X-ray crystallography, single-particle electron microscopy, Cryo-electron tomography, as well as molecular biology and biochemistry.

The applicants are required to have a PhD in biochemistry and/or structural biology. Candidates must have demonstrated profound research experience in structure solution of membrane proteins by X-ray crystallography and/or single-particle Cryo-EM and/or Cryo-ET. It is essential that the candidates are able to work efficiently in the context of an international collaboration and interact with microbiology and chemistry collaborators. Candidates must have a publication record in good and relevant scientific journals.

For interested candidates: please send a CV (listing education, research skills and publications) and a focused letter of motivation to
pos@em.uni-frankfurt.de (deadline: December 31st, 2019)

The positions are available from the beginning of March 2020 for up to 3 years.

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Klaas Martinus Pos, Ph.D.
Professor of Membrane Transport Machineries
Institute of Biochemistry N200/1.09
Goethe-University Frankfurt am Main
Max-von-Laue-Str. 9
D-60438 Frankfurt am Main
Germany
Tel: +49-69-798 29251
Fax: +49-69-798 29201
E-Mail: pos@em.uni-frankfurt.de
Website: www.biochem.uni-frankfurt.de
********************************************

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