We are looking for two PhD students within a MSCA-ITN grant entitled “DNA helicases in genome maintenance: from molecular and cellular mechanisms to specific inhibitors as potential drugs” (AntiHelix). The project aims to obtain a detailed picture of the mechanism of action and the physiological role of a number of DNA helicases that are implicated in human diseases, as well as discover specific inhibitors of those enzymes, which can then be tested as novel therapeutic drugs, especially for cancers. Our role will focus on the structural, biochemical and cellular characterization, with one studentship focussing on RecQ4 and the other on proteins belonging to the FeS helicase family.
More info on the whole project can be found here: https://www.elettra.eu/AntiHelix/
The positions are subjected to the usual MSCA eligibility rules (not more than 4 year from the degree that allows you to do a PhD, and transnational mobility) and will start in February/March 2020.
Our laboratory is located at the Italian synchrotron facility Elettra, Trieste. Elettra is an international research centre, hosting a large number of scientists and users, with a thriving programme of in-house research. The Structural Biology laboratory includes state-of-the-art facilities for cell biology, molecular biology, large scale protein _expression_ and purification, crystallization and structure determination, biochemical and biophysical charaterization. Trieste is a beautiful, multicultural city, at the border between Italy and Eastern Europe and hosts numerous International research centres, having the highest density of scientists in the whole of Europe!
More information on the host laboratory can be found here:
For more information please contact Silvia Onesti: firstname.lastname@example.org
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