[ccp4bb] Job: Senior Scientist - Protein Engineer - Lonza - Cambridge UK

[Daphne Truan <daphne.truan@LONZA.COM>]

Today Lonza is a global leader in life sciences. We are more than 15,000 employees in more than 100 locations around the world. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

A new position has become available in Cambridge for a Senior Scientist experienced in bioinformatics and structure-based protein engineering to join Lonza's Applied Protein Services (APS) Bioinformatics team (all types of proteins considered).

The successful candidate will work on multiple customer projects focusing on in silico assessments and structure-based protein design/engineering. It includes the use of our proprietary platforms for antibody humanisation and deimmunisation, and developability (immunogenicity and manufacturability) risk assessments.

In addition, the role will involve maintenance and development of multiple proprietary platforms.

Key responsibilities:

•To perform structure-based antibody and other protein engineering to enhance the developability of potential biotherapeutics for customers
•To perform expert sequence- and structure-based risk assessments
•Program/script to support the development and maintenance of proprietary platforms and algorithms (knowledge of Python is essential; Perl is an advantage)
•Work in both Linux and Windows environments
•To perform in silico antibody humanisation and deimmunisation
•To perform in silico immunogenicity risk assessments using Lonza’s proprietary Epibase® T-cell epitope prediction platform
•To perform in silico manufacturability risk assessments and antibody aggregation risk prediction using Lonza’s proprietary Sentinel APART platform
•To author high quality reports for clients and in-house development work
•Share responsibility for maintenance and update of software, databases, systems and servers
•To communicate project updates to internal and external clients

Key requirements:

•PhD in Bioinformatics/Structural Biology/Chemistry/Physics with a focus on structure-based protein engineering and molecular modelling preferably with experience in industry
•Structure-based protein engineering and understanding of the molecular interactions
•Experienced working in Linux environment and scripting for maintenance of platforms

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

To apply:
https://lonza.wd3.myworkdayjobs.com/Lonza_Careers/job/UK---Cambridge/Senior-Scientist_R18977

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