|
I am posting this for Shanteri Singh a faculty member here at OU. Please direct any questions to her.
Postdoctoral position available immediately in Singh Group at OU.
Biochemist or Structural Biologist: Seeking a highly motivated postdoc with experience in one or more biochemical techniques involving cloning, protein _expression_, purification, biochemical assays, X-ray crystallography, structure
calculations, and functional characterization of enzymes. The ideal applicant should have a Ph.D. in Biochemistry or related area. The candidate should have expertise in determining X-ray structures of enzymes, functional characterization, and engineering
studies for their potential as biocatalysts for drug development. The focus of the position is to contribute to our ongoing interrogation of substrate specificity and synthetic utilities of prenyltransferases. If you are interested
in applying, please email your CV to
shanteri.singh@ou.edu Research Overview in Singh Group Research in the Singh laboratory lies at the interface of chemistry and biochemistry. We use tools and methods from biochemistry and structural biology to characterize new enzymes from natural product biosynthetic
pathways; molecular biology techniques to engineer enzymes to generate better biocatalysts; and synthetic chemistry methods for the generation of precursors necessary for natural product diversification. The fundamental goal of research in Singh laboratory
is to understand and exploit natural product enzymes for developing biologically active molecules against cancer and infectious diseases. Our lab is especially interested in exploiting the ability of late stage enzymes from natural product biosynthetic pathways
for the structural diversification of complex natural products. Despite the fact that structural diversification of biologically active molecules by attaching different chemical moieties has great potential to generate new drug leads, chemical methods often
suffer from selectivity and tedious purification steps. Our goal is to exploit the potential of natural product enzymes and generate chemoenzymatic-tools for facile attachment of chemical moieties in a stereo- and regio- selective fashion to complex molecules
towards the generation of biologically active compounds. Leonard Thomas, Ph.D.
Macromolecular Crystallography Laboratory Oklahoma COBRE in Structural Biology
Price
Family Foundation Institute of Structural Biology
University of Oklahoma Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center 101 Stephenson Parkway Norman, OK 73019-5251 Office: (405)325-1126 lmthomas@ou.edu http://structuralbiology.ou.edu/mcl To unsubscribe from the CCP4BB list, click the following link: |