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[ccp4bb] Postdoctoral position to study protein synthesis at a molecular level at the University of Texas Med. Branch (UTMB)

There is an open postdoctoral opportunity in my laboratory in the Department of Microbiology and Immunology at the University of Texas Medical Branch (UTMB). The Gagnon laboratory focuses on structural studies of ribosome functional complexes and associated translation factors. We take a combined structure-function approach to study mechanisms of protein synthesis and address how specific ligands, such as translation factors and antibiotics, modulate gene _expression_ by interacting with the translation machinery.

Our laboratory was recently featured on the UTMB Facebook page at:

The advertisement for this position is below.

Postdoctoral position at The University of Texas Medical Branch (UTMB)

We have an immediate opening for a talented, highly motivated postdoctoral scholar in my laboratory at The University of Texas Medical Branch (UTMB) located in Galveston, TX (USA) to study the structure and function of ribosome functional complexes (https://microbiology.utmb.edu/faculty/matthieu-gagnon). The successful candidate will be involved in the characterization of prokaryotic and eukaryotic ribosomes, translation factors and other RNA/protein complexes. The research in our laboratory aims to elucidate the mechanisms of protein synthesis, antibiotic resistance and regulation of translation at a structural level using a combination of macromolecular X-ray crystallography, single-particle cryo-electron microscopy (cryo-EM) and biochemical techniques.

The desired qualifications are:
• Ph.D. in biochemistry, chemistry, biophysics, or a related field;
• Practical skills in molecular biology, protein _expression_/purification, and various biochemical techniques;
• Experience in structural biology (cryo-EM and/or X-ray crystallography);
• Strong interest and motivation to elucidate the molecular mechanisms of protein synthesis and antibiotic resistance through structure determination.

The successful candidate will have an excellent track record and is expected to drive forward the projects, act independently or semi-independently, compile, analyze and write up data for publication, assist with the training of graduate students and work co-operatively with others.

Structural biology facilities at UTMB are outstanding (https://www.utmb.edu/core). Our cryo-electron microscopy (cryo-EM) core facility recently acquired the FEI Titan Krios high-voltage (300 kV) electron microscope equipped with two direct detector cameras, Falcon 3 (ThermoFisher) and K3 (Gatan), ideal setup for high-resolution structure visualization. Other cryo-EM resources include a JEOL 2200FS cryo-EM microscope equipped with a DE20 direct electron detector for high-resolution imaging work and a liquid nitrogen autofilling system allowing week-long experiments, a cryo-microscope JEOL 2100, an FEI vitrobot cryo-plunger, a Leica EM-GP2 cryo-plunger, a Gatan Solarus plasma cleaner. X-ray crystallography resources include two X-ray area detector systems, a Phoenix crystallization robot, a Minstrel crystal imaging robot, the Alchemist and epMotion liquid handling robots. Other state-of-the-art facilities include NMR, next-generation sequencing, molecular genomics, high-throughput screening, solution biophysics, optical microscopy and computational biology.

Ample opportunities exist at UTMB for interactions with centers of scientific excellence in structural biology and molecular biophysics, biodefense, molecular medicine, cancer biology, infectious diseases, environmental health, aging, and translational sciences (https://www.utmb.edu/centers). Moreover, UTMB boasts a renowned, vibrant and highly active community of infectious disease researchers and clinicians, providing ample opportunities for broader collaborations and development.

Review of applications will begin immediately and will continue until the position is filled. Interested applicants should send their CV along with a cover letter briefly describing their research accomplishments, current research interests and contact information for three references in a single PDF directly to Dr. Matthieu Gagnon at magagnon@utmb.edu.

Matthieu G. Gagnon, Ph.D.
Assistant Professor
Department of Microbiology & Immunology
Sealy Center for Structural Biology & Molecular Biophysics
The University of Texas Medical Branch
301 University Blvd., Galveston, TX 77555-1019
4.104C Medical Research Building
Email: magagnon@utmb.edu
Phone: 409-772-2326

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