[Date Prev][Date Next][Thread Prev][Thread Next][Date Index][Thread Index]

[ccp4bb] PhD student position on structure of amyloid fibrils (cryo-EM)

PhD student position at the Institute of Protein Biochemistry, Ulm University (Germany),
Group Prof. Dr. M. Fändrich

The Institute of Protein Biochemistry (https://www.uni-ulm.de/nawi/nawi-pbc.html) investigates the molecular basis of amyloid diseases, such as Alzheimer's disease and systemic amyloidosis. We use a broad range of techniques from protein biochemistry, structural biology (in particular cryo-EM) to cell biology. Our strong ties to several medical institutions enable us to uniquely link structural biology with patient and animal samples. We seek for new doctorate students with a very good Master degree in, for example, Biochemistry, Chemistry or Physics to strengthen our cryo-EM analysis of amyloid fibril structures. Projects may involve protein purification and sample preparation, cryo-EM imaging, single particle reconstruction, structural modelling and the combination of structural and biological/medical data.
Recent references:
Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids. Liberta F, Loerch S, Rennegarbe M, Schierhorn A, Westermark P, Westermark GT, Hazenberg BPC, Grigorieff N, Fändrich M, Schmidt M. Nature Comm. 10, 1104 (2019)
Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis. Radamaker, L, Lin Y-H, Annamalai K, Huhn S, Hegenbart U, Schönland SO, Fritz G, Schmidt M, Fändrich M. Nature Comm. 10, 1103 (2019)
If you are interested, please contact us under bewerbung-pbc(at)uni-ulm.de. Incoming mails will be viewed from 15 April 2019 onwards. Position will be filled as soon as possible.

To unsubscribe from the CCP4BB list, click the following link: