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A Post Doctoral Fellow position is immediately available in the laboratory of Dr. Emmanuel Skordalakes at The Wistar Institute. The laboratory studies protein, nucleic acid assemblies that participate in the replication and maintenance of telomeres and have been implicated in a host of diseases including cancer. Areas of interest include the telomere replication and maintenance nucleoprotein complexes telomerase, CST and shelterin. We use a multidisciplinary approach involving biochemical, biophysical and cell based assays to address mechanistic questions related to the function of the above protein-nucleic acid assemblies. Our goal is to understand how telomeres are replicated, how shelterin and CST regulate this process and how dysfunction of these complexes leads to human disease. Information obtained from these studies will be used to identify activity modulators of telomerase and associated complexes as potential therapeutics for cancer and age-related diseases. We are looking for highly motivated candidates that have recently acquired or will be acquiring a Ph.D. in biochemistry, structural biology or a related field and have a record of peer reviewed publications. Additional information regarding our research program can be found at the laboratory's web sites http://webdev.chem.upenn.edu/chem/research/faculty.php?id=52 http://www.wistar.org/lab/emmanuel-skordalakes-phd Interested applicants should e-mail their CV along with a cover letter briefly describing their research accomplishments and current research interests to Emmanuel Skordalakes, Ph.D., Associate Professor (skorda@wistar.org). The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. Research discoveries conducted at Wistar have led to the development of vaccines; the identification of genes associated with cancers; and the development of many other significant research technologies and tools. We offer an excellent benefits package.
Emmanuel Skordalakes, Ph.D.
Associate Professor
Gene _expression_ and Regulation Program
The Wistar Institute
215-495-6884 Office
215-898-2202 Lab
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