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[ccp4bb] Structural biology and assay development/biophysics positions available at ICR, London, UK

The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

The Cancer Research UK Cancer Therapeutics Unit (CTU), within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The CTU’s exciting goal is to discover high quality small molecule drug candidates and to progress these to clinical trial. All the scientific disciplines are in place to make this possible, including assay development and screening, medicinal chemistry, biology, structural biology, metabolism and clinical specialists.

Two postdoctoral positions in Structural Biology (ID 642) and a Higher Scientific Officer position in protein production, assay development and biophysics (ID 645) are available in Dr Rob van Montfort’s Hit Discovery and Structural Design (HDSD) Team within the CTU.

The postdoctoral researchers in structural biology will be involved in X-ray crystallography, fragment-based screening and structure-based drug design and will be responsible for protein _expression_, purification, crystallisation, structure determination and structural analysis of protein-ligand complexes from one of the CTU’s drug discovery programmes. The successful candidates will also be part of the Division of Structural Biology, in which the crystallographers in Dr van Montfort’s team are embedded, and will have access to state of the art crystallisation facilities, an in-house X-ray source and excellent access to synchrotrons. The successful candidate will interact closely with the biology, computational chemistry and medicinal chemistry teams at the CTU, and will therefore be expected to work across the two sites in Chelsea, London and Sutton, Surrey. Applicants must have a PhD in a biological or physical science, and experience in macromolecular crystallography (to include protein biochemistry, protein crystallisation, & protein crystallography). Experience in molecular biology, protein _expression_ in insect cells, structure-based drug design, and/or biophysics will be an advantage. The starting salary for the positions will be in the range £31,023 to £39,473 p.a. inclusive (based on previous post-doctoral experience). One position is funded for one year and one is funded for two years. Applicants will automatically be considered for both positions. Informal enquiries can be made via email to rob.vanmontfort@icr.ac.uk or yann-vai.lebihan@icr.ac.uk.

The higher scientific Officer protein production, assay development and biophysics will be involved in establishing the _expression_, purification and characterisation of one of our early stage drug targets, using contemporary _expression_ systems and purification methods available within the HDSD team. The postholder will be based in Sutton. In addition, the post-holder is expected to characterise ligand and inhibitor binding to the recombinant proteins using biochemical assays and biophysical methods such as Thermal-shift assays, surface plasmon resonance (SPR), isothermal titration calorimetry (ITC) and ligand-based NMR methods. The successful candidate will be an integral member of a multidisciplinary project team and will interact closely with the biologists, computational chemists, medicinal chemists and structural biologists. Applicants must have a BSc in a biochemistry or related biological subject and in depth technical laboratory experience in protein _expression_ and purification methodologies. Expertise in insect cell _expression_, assay development and/or knowledge of protein NMR methods would be advantageous. The starting salary for the position will be in the range of £33,285 to £37,359 p.a. inclusive (based on previous experience) and the post is offered on a fixed term contract of 1 year. Informal enquiries to rosemary.burke@icr.ac.uk or rob.vanmontfort@icr.ac.uk

Please DO NOT send your application to Dr van Montfort, Dr Burke or Dr Le Bihan. Applications will only be considered if made via the e-recruitment system on our website www.icr.ac.uk.

Dr. Rob van Montfort
Team Leader Hit Discovery and Structural Design
Divisions of Cancer Therapeutics and Structural Biology
The Institute of Cancer Research
15 Cotswold Road
Sutton SM2 5NG

+44-(0)20-8722-4364 (Sutton)
+44-(0)20-7153-5142 (Chelsea)

The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP.

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