[ccp4bb] Research Associate Position in Chemical Glycobiology (Francis Crick Institute)

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Deadline 1 Feb, 2019

https://www.imperial.ac.uk/jobs/description/NAT00344/research-associate-position-chemical-glycobiology-francis-crick-institute/

Job Summary:

Up to two Postdoctoral Research Associate positions are available in the Chemical Glycobiology Laboratory hosted by the Department of Chemistry at Imperial College London and located at the Francis Crick Institute, one of the world’s leading biomedical research institutes (https://www.crick.ac.uk/research/labs/ben-schumann).

The Chemical Biology Lab led by Dr Ben Schumann is performing research at the interface between chemistry and state-of-the-art biology. Our integration in a network of world-class biomedical research at the Francis Crick Institute is a unique opportunity to approach problems at the forefront of biology. Our association with Imperial College London enables frequent exchange with pre-eminent chemists and chemical biologists. The posts are fully core-funded, including access to outstanding Science Technology Platforms at the Francis Crick Institute with state-of-the-art equipment in all areas of chemical and biological research.

We are aspiring to close the gap between glycan chemistry and modern biology by developing novel “precision tools” to understand the role of glycans in biological processes in unprecedented detail. To this end, we combine techniques of chemical or chemo-enzymatic synthesis, bioorthogonal ligation, protein engineering, molecular and cell biology including CRISPR-based genome engineering, imaging and structural biology. Our focus lies in understanding the intricacies of glycosylation in the secretory pathway. As an example, we engineer enzymes involved in the formation of glycoconjugates and use them in combination with chemically modified substrates to unravel how specific glycan subsets modulate biological processes. These studies are essential to develop new disease biomarkers and glycan-based therapies.

Highly motivated candidates with a strong background in chemical biology, biochemistry, organic chemistry or glycobiology are encouraged to apply. A strong interest in interdisciplinary, glycan-based research is expected and should be reflected in the application.

Duties and responsibilities

To lead, conduct and record research at the forefront of modern chemical glycobiology
To contribute to other projects, internal and external, on a collaborative basis
To draft and submit publications to refereed journals
To actively engage in promoting the lab’s research
To actively learn new skills and integrate them in the lab’s research
To champion a motivating, collaborative work environment
To co-supervise PhD, Masters and undergraduate students

Essential requirements

A PhD or equivalent level of professional qualifications in a relevant field (e.g. chemical biology, chemistry, biochemistry)
A strong interest in chemical glycobiology
Practical experience in leading a multi-disciplinary research project
A proven publication track record in their respective field (where publications are under preparation, please provide a concise research summary of not more than two pages). Please indicate own contributions.
Ability to work independently and within a team
Eagerness to learn new techniques

Further information

Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £33,380 - £35,061 per annum.

The Department of Chemistry proudly holds an Athena SWAN Gold Award and strives to provide a working environment where all our staff feel fully supported to flourish and excel. The Department of Chemistry is committed to promoting the wide range of Family Friendly policies and associated initiatives offered by the College.

For informal enquiries about this position please contact Dr Ben Schumann (ben.schumann@crick.ac.uk).

For any technical queries during the application process please contact: recruitment@imperial.ac.uk.

For other queries, please contact Nayrin Noori: n.noori@imperial.ac.uk.

Committed to equality and valuing diversity. Imperial College is also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and is working in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.
http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/

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