Introduction

Invited Speakers’ Contributions

The chemistry of heavy atom attachment

J. Drenth, University of Groningen

Heavy atom derivative screening

A.G.W. Leslie, MRC Cambridge

Heavy atom location using SHELXS-90

G.M. Sheldrick, University of Göttingen

Locating heavy atom sites by automatic Patterson search — GROPAT

Y. Jones and D. Stuart, University of Oxford

Refinement of heavy-atom parameters and isomorphous phasing

P.R. Evans, MRC Cambridge

A maximum-likelihood theory of heavy-atom parameter refinement in the isomorphous replacement method

G. Bricogne, L.U.R.E. Paris and MRC Cambridge

Dealing with imperfect isomorphism in multiple isomorphous replacement

R.J. Read, University of Alberta, Edmonton

Maximum likelihood refinement of heavy atom parameters

Z. Otwinowski, Yale University

Refinement of single isomorphous replacement heavy-atom parameters in Patterson vs reciprocal space

I.J. Tickle, Birkbeck College

Multiwavelength anomalous diffraction analysis of a large protein

J.L. Smith, E.J. Zaluzec, J.-P. Wery, Purdue University and Y. Satow, University of Tokyo

Heavy atom refinement against solvent-flattened and local-symmetry averaged phases

V. Cura, A.D. Podjarny, S. Khrishnaswamy, B. Rees, J.M. Rondeau, F. Tete, L. Mourey, J.P. Samama and D. Moras, LCB Strasbsourg

The structure determination of Galactose Oxidase by multiple isomorphous replacement with anomalous scattering

N. Ito, University of Leeds

Theory and practice in the use of heavy atom substitution

E.J. Dodson, University of York

Native non-isomorphism in the structure determination of Heat Labile Enterotoxin(LT) from E. coli

T.K. Sixma, S.H. Pronk, A.C. Terwisscha van Scheltinga, A. Aguirre, K.H. Kalk, G. Vriend and W.G.J. Hol, University of Groningen

Phase determination using mercury derivatives of engineered cysteine mutants

K. Nagai, P.R. Evans, J. Li, Ch. Oubridge, MRC Cambridge

Establishment of a heavy-atom databank for protein structures

D. Carvin, S.A. Islam, M.J.E. Sternberg and T.L. Blundell, Birkbeck College and Imperial Cancer Research Fund Laboratories, London

Heavy atom studies at EMBL Hamburg

Z. Dauter, EMBL Hamburg