DL/SCI/R22

BIOLOGICAL SYSTEMS:

STRUCTURE AND ANALYSIS

March 1984

 

Foreword

(iii)

The structures and catalytic mechanisms of molybdenum in enzymes studied by e.p.r. and X-ray spectroscopy.

By R.C. Bray

1

XANES of metal ions in biological molecules.

By A. Bianconi

8

NMR and EXAFS studies of metallodrugs and metalloproteins.

By S.J. Berners Price, M. Ismail, M.A. Mazid, M.T. Razi, P.J. Sadler and G.N. Greaves

18

Synchrotron radiation studies of large proteins and supramolecular structures.

By Michael G. Rossmann

28

Applications of anomalous dispersion to the determination of protein structures in crystals.

By J.R. Helliwell, D.W.J. Cruickshank, G.H. Ellis, J. Habash, M.Z. Papiz, S. Rule and J.M.A. Smith

41

X-ray and neutron studies of non-crystalline biological materials.

By A. Miller, R. Greenall, S.K. Burley, R. Ruigrok, P.C.J. Krygsman and C. Nave

60

A comparative study of the crystallographic analysis and EXAFS of insulin and haemoglobin.

By G.G. Dodson

65

Interference and limits of detection in analyses of trace elements in biological systems.

By C.F. Mills

73

Trace element analysis in biological samples using synchrotron radiation.

By H. Prins, S.T. Davies and A.J.J. Bos

78

Medical imaging with synchrotron radiation.

By E. Rubenstein

86

Time resolved X-ray scattering and diffraction: the example of clathrin assembly.

By G.R. Jones, G.P. Diakun, S. Slawson, G.R. Mant and J. Bordas

90

The effects of ligands on the dynamics of microtubule assembly and disassembly studied by time-resolved low angle X-ray scattering.

By D. Starling

102

X-ray diffraction studies of the polynucleotides poly d(A-T).poly d(A-T) and poly d(G-C).poly d(G-C).

By W. Fuller, W.J. Pigram, A. Mahendrasingam, V.T. Forsyth, C. Nave and R.J. Greenall

106

Two left-handed double-helical conformations for the potassium salt of the polynucleotide poly d(G-C).poly d(G-C).

By A. Mahendrasingam, W.J. Pigram, W. Fuller, V.T. Forsyth and R.J. Greenall

109

Time resolved X-ray fibre diffraction studies on the polynucleotide.

By V.T. Forsyth, R.J. Greenall, A. Mahendrasingam, C. Nave, W.J. Pigram and W. Fuller

112

Is DNA a double helix?

By R.J. Greenall, A. Mehendrasingam, V.T. Forsyth, W.J. Pigram and W. Fuller

115

An X-ray and neutron small-angle scattering study of the structure of insect iridovirius IV29.

By S.K. Burley, R.J. Greenall, A. Miller, M.T. Stubbs, C. Nave and D.C. Kelly

118

Neutron scattering studies on glycoproteins.

By S.J. Perkins

121

A new instrument for protein crystallography on the wiggler line of the SRS.

By J.R. Helliwell, M.Z. Papiz, P.R. Moore and A.W. Thompson

123

EXAFS studies on milk calcium phosphate.

By J.C. Irlam, D.W.L. Hukins, S.S. Hasnain, N. Binsted and C. Holt

128

Dopamine-b-monooxygenase, investigation of the copper sites by EXAFS and EPR spectroscopy.

By N.J. Blackburn, D. Collison, G.P. Diakun and S.S. Hasnain

131

Biogenic amorphous pyrophosphate deposits.

By G.N. Greaves, K. Simkiss, M. Taylor and N. Binsted

133