DLCONF96001
MACROMOLECULAR REFINEMENT
January, 1996
Introduction 

Acknowledgements 

Invited Speakers’ Contributions 

The limits of interpretation Dale E Tronrud, Oregon 
1 
Protein precision reexamined: Luzzati plots do not estimate final errors D W J Cruikshank, Manchester 
11 
Review: crossvalidation and the freeR Kevin Cowtan, York 
23 
Selfvalidation: an extended Hamilton test Alessia Bacchi, Victor S Lamzin and Keith S Wilson, Hamburg 
29 
Full matrix least squares Lynn F Ten Eyck, San Diego 
37 
Leastsquares refinement of macromolecules: estimated standard deviations, NCS restraints and factors affecting convergence George M Sheldrick, Göttingen 
47 
Torsion angle dynamics refinement of the Chaperonin GroEL at 2.8 Å resolution Paul D Adams, Kerstin Braig, Luke M Rice, and Axel T Brünger, Yale 
59 
Real space refinement as a tool for model building Tom J Oldfield, York 
67 
Improved structure refinement through maximum likelihood Navraj S Pannu and Randy J Read, Edmonton 
75 
Maximumlikelihood structure refinement: theory and implementation within BUSTER + TNT Gérard Bricogne and John Irwin, LMB, Cambridge 
85 
Application of maximum likelihood methods for macromolecular refinement Garib N Murshudov, Eleanor J Dodson, York, Alexei A Vagin, Belgium 
93 
Xray analysis of domain motions in protein crystals David S Moss, Ian J Tickle, O Theis and A Wostrack, Birkbeck College 
105 
Group anisotropic thermal parameter refinement of the lightharvesting complex from purple bacteria Rhodopseudomonas acidophila Miroslav Z Papiz, Daresbury Laboratory, and Steve M Prince, Glasgow 
115 
Is refinement from a random start possible? — given diffraction data to medium resolution — Pier Gros, Utrecht 
125 
What we can learn from anisotropic temperature factors? Thomas Schneider, Hamburg 
133 
Sharpened maps for more effective refinement in protein crystallography Susanna Butterworth, Victor S Lamzin, and Keith S Wilson, Hamburg 
145 
Removing bias from a model for HIV1 reverse transcriptase by real space averaging between different crystal forms Robert Esnouf, Jinshan Ren, Yvonne Jones, David Stammers and Davis S. Stuart, Oxford 
153 
Improving electron density maps calculated from weak or anisotropic data S.J. Gamblin, NIMR, Mill Hill, and D.W. Rodgers and T. Stehle, Harvard 
163 
Pseudo symmetry David Watkin, Oxford 
171 
Likelihoodweighted real space restraints for refinement at low resolution J.P. Abrahams, LMB, Cambridge 
185 
Weighting diffraction data G David Smith, Buffalo 
193 