The research group headed by Prof. Dr. Dietmar Manstein invites applications for a PhD position funded by the Health Research Framework Programme of the German Federal Government and the European Joint Programme on Rare Diseases under the call “Transnational Research to Accelerate the Diagnosis and/or Investigation of Disease Processes and Mechanisms in Rare Diseases"
The work is performed in the context of a multidisciplinary, international research team that includes participants from France, Italy, Hungary and Germany.
The PhD project involves structural studies of actin mutants, molecular motors and their complexes. The Manstein laboratory is offering excellent working conditions and a stimulating research environment. We typically use hybrid approaches that combine X-ray crystallography, serial crystallography, electron microscopy, time-resolved spectroscopy, and in silico modelling. The work is in part conducted at synchrotron facilities in Germany and France. The salary is in accordance to the German Public Sector Collective Agreement (TV-L E13/58%). The position is available from July 1, 2020.
Chinthalapudi, K., Heissler, S. M., Preller, M., Sellers, J. R. & Manstein, D. J. 2017. Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C. Elife, 6(e32742), DOI: 10.7554/eLife.32742.
Latham, S. L., Ehmke, N., Reinke, P. Y. A., Taft, M. H., et al.., Manstein, D. J. & Di Donato, N. 2018. Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia. Nat Commun, 9(1), pp 4250, DOI: 10.1038/s41467-018-06713-0.
Radke, M. B., Taft, M. H., Stapel, B., Hilfiker-Kleiner, D., Preller, M. & Manstein, D. J. 2014. Small molecule-mediated refolding and activation of myosin motor function. Elife, 3(e01603), DOI: 10.7554/eLife.01603.
von der Ecken, J., Heissler, S. M., Pathan-Chhatbar, S., Manstein, D. J. & Raunser, S. 2016. Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution. Nature, 534(7609), pp 724-8, DOI: 10.1038/nature18295.
For more information, please refer to the website:
Please send your application by electronic mail and preferably in one single pdf-document to
Joanna D. Schille, BA
Medizinische Hochschule Hannover, Fritz-Hartmann-Centre for Medical Research
Institute for Biophysical Chemistry and Structural Biochemistry OE 4350
For full consideration, the application should include a cover letter, a detailed CV, copies of all educational certificates and transcripts of records, a summary of previous research, and the address details of two academic advisors who can provide letters of recommendation. The deadline for application is June 30, 2020. Early applications are encouraged; applications may be processed as they are received.
MHH is an equal opportunity employer. Qualified women are therefore particularly encouraged to apply. Applicants with disabilities are treated with preference given comparable qualification.
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