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Dear all, I am looking to recruit two post-doctoral researchers experienced in cryo-EM, cryo-ET, or X-ray crystallography. The projects are focused on characterizing the replication of viruses in situ: We study the infection of enteroviruses by a combination of FIBM and cryo-ET to determine the mechanism of enterovirus genome delivery into a host cell and changes in intra-cellular organization induced by infection. We complement the whole-cell studies by high-resolution cryo-EM of virus genome release under biologically relevant conditions in vitro. We employ cryo-ET and light microscopy to characterize the mechanisms that tailed phages, potential phage therapy agents, employ to invade a biofilm and infect bacteria. We use the cryo-ET to determine the functions of bacterial factors in phage genome delivery and characterize phage assembly. We employ time-lapse fluorescence microscopy to establish the relationship between the stage of biofilm development and its susceptibility to phage infection. Details about my research group can be found here: Our in house cryo-EM facility: https://www.ceitec.eu/cryo-electron-microscopy-and-tomography-core-facility/cf94 Please get in touch with me if you have any questions. Pavel ################################
Pavel Plevka Laboratory of Structural Virology CEITEC, Masaryk University Kamenice 5 / A35 Brno, 625 00, Czech Republic Phone: +420 549 49 7756 ############################### To unsubscribe from the CCP4BB list, click the following link: |