We are interested in recruiting an enthusiastic and talented individual at the post-doctoral level with experience in structural biology and biochemistry to join a team investigating how complex macromolecular interactions in the human DNA-damage response (DDR) are regulated by post-translational modifications such as phosphorylation and ubiquitination. A range of projects are available in the lab but of particular interest are recruitment mechanisms that localise DDR complexes to chromatin through post-translational modifications of histones and their interacting proteins. The research will be carried out in the laboratory of Steve Smerdon (https://www.birmingham.ac.uk/staff/profiles/cancer-genomic/smerdon-steve.aspx) at the Institute of Cancer and Genomic Sciences (ICGS) located within the University of Birmingham Medical School in the UK. Experimental approaches will be highly multi-disciplinary with a focus on structural characterisation using X-ray crystallography and EM/cryo-EM, and the work will benefit from close interactions with a network of collaborators worldwide and a cluster of world-class laboratories within the ICGS interested in DDR biology.
References to some of our earlier work: Kyrieleis, O.J.P. et al. (2016) Cell Reports, 17, 3099 / Hořejší, Z. et al. (2014) Cell Reports, 7, 19 / Rock, J.R. et al. (2013) Science 340, 871 / Lloyd, J. et al., (2009) Cell 139, 100 / Stucki, M. et al. (2005) Cell 123, 1213 / Clapperton, J.A. (2004) Nat. Struct. Mol. Biol. 11, 512 / Elia, E.H.A. et al. (2003) Cell 115, 83.
The position is a full-time post-doctoral appointment with an initial duration of 36 months and salary commensurate with age and experience. Post is available immediately but start date is negotiable.
Further details about applying, Ts&Cs etc can be found here at:
For more information or informal discussions contact me at S.J.Smerdon@bham.ac.uk
Professor of Structural Biology
Institute of Cancer and Genomic Sciences
1st Floor IBR West (WX 1.19)
University of Birmingham,
Vincent Drive, Edgbaston,Birmingham,
Office: +44(0)121 414 9241
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