A post-doctoral position is available to study the mechanistic role of transcription factors in hematopoiesis and leukemogenesis at the structural level in the laboratory of Susan Chan and Philippe Kastner, at the Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg, France () in collaboration with the Department of Integrated Structural Biology.
The IGBMC is a component institute of the CERBM (European Centre for Research in Biology and Medicine) and one of the leading centres in biomedical research in France and Europe. It is well equipped for molecular, cellular and structural biology, as well as genetic and animal experimentation. The department of Integrated Structural Biology is located in the new Centre for Integrative Biology (CBI), which is part of the European distributed Structural Biology Infrastructure (Instruct) and is well equipped for structural investigations using state-of-the-art X-ray diffraction equipment and cryo electron microscopes (Titan Krios and Polara microscopes).
The project will aim at unveiling the architecture of transcriptional complexes with a multipronged structural and functional approach. This project will require the production, characterization and structural investigation of transcription factor-associated complexes. To achieve this goal, a range of techniques encompassing molecular biology, biochemistry and biophysical characterization, will be employed. The Postdoctoral Research fellow will benefit from access to the Structural Biology and Genomics platform at IGBMC (cloning, purification, crystallization).
Candidates must have a Ph.D. degree, a keen interest in structural biology, and should enjoy working as part of an interdisciplinary team. They should have a background in at least one of the following areas: molecular biology; biochemistry, in particular protein _expression_ and purification; biophysics; X-ray crystallography; cryo electron microscopy. We welcome highly qualified and motivated individuals, with a recently obtained PhD in structural biology and first author publications in peer-reviewed international journals, who can work easily in a multi-lab consortium. This position is available immediately and is funded for two years.
Please send a detailed CV with list of publications, a letter of motivation, and the names of three references to Susan Chan and Philippe Kastner (firstname.lastname@example.org).
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