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PhD position at NUI Galway, Ireland
The Crowley laboratory is recruiting a PhD candidate to begin in September 2019. This four year fully-funded project is part of SFI research centre SSPC-Pharm5, and includes an annual stipend, registration
fees, consumables costs and travel allowance.
We are looking for a highly motivated PhD candidate with a passion for protein science. Applications are welcome from BSc or MSc graduates of Chemistry, Biochemistry or Biotechnology. Prior experience in
protein purification is an advantage.
Controlled protein assembly provides a means to construct biocompatible, nanoscale devices and functional materials. We are interested in ligands that facilitate protein assembly and crystallization. Such “molecular
glues” trigger assembly by providing a surface on which two or more proteins can associate. Macrocycles such as calixarenes and cucurbiturils are versatile "glues" for protein assembly and crystallization.[1-4] We have shown how sulfonato-calix[8]arene can
control the assembly of lysine-rich cytochrome c.[3] Different types of assemblies were generated depending on the protein – calixarene ratio. While our work to date has focused on cationic proteins[1,4] now we will expand the scope to include neutral proteins.
Our main interest is to discover methods of generating porous assemblies with potential applications in sensing and catalysis.
- motivation statement (~500 words)
- 2 page CV - contact details for 2 referees - PDF of BSc or MSc thesis
References 1. McGovern RE, Fernandes H, Khan AR, Power NP, Crowley PB Protein camouflage in cytochrome c - calixarene complexes. Nature Chem. 2012, 4, 527-533.
2. Guagnini F, Antonik PM, Rennie ML, O'Byrne P, Khan AR, Pinalli R, Dalcanale E, Crowley PB Cucurbit[7]uril-dimethyllysine recognition in a model protein. Angew. Chem. Int. Ed. Engl. 2018, 57, 7126-7130.
3. Rennie ML, Fox GC, Pérez J, Crowley PB Auto-regulated protein assembly on a supramolecular scaffold. Angew. Chem. Int. Ed. Engl. 2018, 57, 13764-13769.
4. Alex JM, Rennie ML, Engilberge S, Lehoczki G, Dorottya H, Fizil Á, Batta G, Crowley PB Calixarene-mediated assembly of a small antifungal protein. IUCrJ 2019, 6, 238–247.
Prof. Peter Crowley School of Chemistry National University of Ireland, Galway
Ireland
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