Postdoctoral Position at the Institute of Protein
Biochemistry, Ulm University (Germany),
Group Prof. Dr. M. Fändrich
The Institute of Protein Biochemistry (https://www.uni-ulm.de/nawi/nawi-pbc.html)
investigates the molecular basis of amyloid diseases, such as
Alzheimer's disease and systemic amyloidosis. We use a broad
range of techniques from protein biochemistry, structural
biology (in particular cryo-EM) to cell biology. Our strong ties
to several medical institutions enable us to uniquely link
structural biology with patient and animal samples. We seek for
new postdoctoral co-workers with a strong background in cryo-EM
or X-ray crystallography to strengthen our cryo-EM projects on
amyloid fibril structures. Projects may involve protein
purification and sample preparation, cryo-EM imaging, single
particle reconstruction, structural modelling and the
combination of structural and biological/medical data.
Recent
references:
Cryo-EM
fibril structures from systemic AA amyloidosis reveal the
species complementarity of pathological amyloids.
Liberta
F, Loerch S, Rennegarbe M, Schierhorn A, Westermark P,
Westermark GT, Hazenberg BPC, Grigorieff N, Fändrich M, Schmidt
M.
Nature Comm. 10, 1104 (2019)
Cryo-EM
structure of a light chain-derived amyloid fibril from a patient
with systemic AL amyloidosis.
Radamaker, L,
Lin Y-H, Annamalai K, Huhn S, Hegenbart U, Schönland SO, Fritz
G, Schmidt M, Fändrich M.
Nature Comm.
10, 1103 (2019)
If you are interested, please contact us under bewerbung-pbc(at)uni-ulm.de.
Incoming mails will be viewed from 15 April 2019 onwards.
Position will be filled as soon as possible.
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