The Frederick National Laboratory for Cancer Research (FNLCR) is looking for an NMR Spectroscopy (Sr. Scientist) an experienced, hands-on NMR Spectroscopist to provide support for multiple projects in a fast-paced environment of a highly collaborative team of biophysicists, chemists, biochemists, structural, cell, and molecular biologists. FNLCR serves as the hub for the NCI RAS Initiative program. One of the major objectives of the RAS Initiative is to carry out structure-based drug discovery to identify lead compounds against RAS-driven cancers. The candidate will join the RAS Initiative and lead the projects on developing and optimizing small molecules for use as RAS inhibitors.
Detailed information is attached below. To apply for this position, please use this link:https://leidosbiomed.csod.com/ats/careersite/JobDetails.aspx?site=4&id=276
Principal Scientist, Team Lead - RAS Structural Biology
NCI RAS Initiative
Frederick National Laboratory for Cancer Research
8560 Progress Drive, C1012,
Frederick, MD 21701 USA
NMR Spectroscopy - Sr. Scientist
Job ID: req276
Facility: Frederick: ATRF
Location: 8560 Progress Dr, Frederick, MD 21701 USA
The Frederick National Laboratory is dedicated to improving human health through discovery and innovation in the biomedical sciences, focusing on cancer, AIDS, and emerging infectious diseases. The RAS Initiative is seeking an experienced, hands-on NMR Spectroscopist to provide support for multiple projects in a fast-paced environment of a highly collaborative team of biophysicists, chemists, biochemists, structural, cell, and molecular biologists. Our focus is to understand the biology of RAS protein/ RAS at the plasma membrane, and to develop therapies for RAS-driven cancers.
- Designing, developing, and implementing NMR-based experiments to support drug discovery projects, and characterizing RAS:effector interactions, and RAS:small-molecule interactions in solution, and at the plasma membrane/membrane mimetics.
- Developing advanced NMR methods applied to structure-function studies of bio macromolecules, with the goal of understanding their interactions and responses to various ligands, both small molecule compounds and protein binding partners.
- Work in a fast-paced environment, providing NMR support to the FNL/NCI RAS Initiative
- Work closely with a highly collaborative multidisciplinary team of chemists, biochemists, structural and cell biologists, to discover, develop, and optimize pharmaceutical agents for use as RAS inhibitors
- Design and conduct NMR experiments, collect and analyze data
- Maintain in-house NMR spectrometer
- Solve NMR structures of RAS protein in complexes with relevant small molecule inhibitors
- Provide biophysics support for drug/protein interaction analysis
- Work independently, however within highly collaborative team environment
- Possession of a doctorate degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency
- In addition to the educational requirements, a minimum of five (5) years of post-doctoral experience in protein NMR is required
- Working knowledge of multidimensional heteronuclear NMR experiments for elucidation of protein structure
- Strong background in NMR spectroscopy
- Expertise in protein NMR, including analysis of protein-drug interactions, protein complexes, and proteins on membrane/membrane mimetics
- Must be highly collaborative, with excellent communication skills, self-motivated, and team-oriented
- Must be able to obtain and maintain a security clearance
- Experience with RAS family proteins NMR
- Experience with NMR analysis of RAS family proteins interacting with effectors/binding partners
- Experience with SPR, ITC, and other biophysical techniques to measure protein-drug interaction is a plus
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)